Gheyath K. Nasrallah

Postdoctoral Fellow

Email: gheyath.nasrallah@iwk.nshealth.ca 

Gheyath (Goos) is a medical technologist by profession. He completed his PhD at Dalhousie University, Department of Microbiology and Immunology, in 2011. During his PhD, Gheyath used the yeast and the tissue culture model to explore the role of two bacterial genes, htpB & potD, in the pathogenesis of the fresh water pathogen Legionella pneumophila. Gheyath recently joined the Berman laboratory as a postdoctoral fellow to work on a Genome Canada-funded project entitled: Identifying Genes and Novel Therapeutics to Enhance Treatment (IGNITE). The IGNITE group will use the powerful genetic tools of yeast, zebrafish, tissue culture, and mouse models to discover novel genes responsible for a number of orphan diseases (ODs) prominent in Atlantic Canada. This multi-pronged approach will function as a pipeline to identify the underlying genetic lesions, validate the phenotype, and ultimately serve as a platform for developing small molecules and drugs targeting these ODs. Gheyath will be leading the efforts using the molecular biology tools afforded by the zebrafish model including phenotype characterization, morpholino knockdown injections, generation of transgenic models of the human disease, and chemical screens in the zebrafish embryos.

Publications:

  • Nasrallah GK, A. L. Riveroll, A. Chong, L. E. Murray, P. J. Lewis, and R. A. Garduno.  2011.  Legionella pneumophila requires polyamines for optimal intracellular growth. Journal of Bacteriolgy. 193: 4346-4360
  • Nasrallah GK, Tompkins T, Carson CR, and Garduno RA. (2011). The putative spermidine-binding protein PotD enhances the early intracellular growth of Legionella pneumophila. Infection and Immunity. Submitted 
  • Nasrallah GK, Orton D, Ganion E, and Garduno RA. (2011) The htpAB operon of Legionella pneumophila can not be genetically complemented by the groE operon of Escherichia coli. Canadian Journal of Microbiology. In press
  • Garduno GA, Chong A, Nasrallah GK, and Allan DS. (2011) The Legionella pneumophila chaperonin – an unusual multifunctional protein in unusual location. Frontiers in Microbiology. 2:1-12. Review
  • Nasrallah GK. (2011). PhD thesis. Potential Roles of the chaperonin (HtpB), polyamines, and the polyamine binding protein (PotD) in L. pneumophila pathogenesis. Dalhousie University, Halifax, NS, Canada. http://hdl.handle.net/10222/14200
  • Da’as S, Teh ME, Dobson TD, Nasrallah GK, Wang H, Neuberg DS, Marshall JS, LinTJ, and Berman JN. (2010) Zebrafish mast cells possess an FcεRI-like receptor and participate in innate and adaptive immune responses. Developmental and Comparative Immunology, 5L 125-134.
  • AbuOdeh R, Yasin S, Nasrallah G, Babi Y. (2010) Rates of infection and phylogenetic analysis of GB virus C among Kuwaiti and Jordanian blood donor. Intervirology, 53:402-407.
  • Chong A, Lima CA, Allan DS, Nasrallah GK, and Garduño RA. (2009) The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization. Infection and Immunology, 77: 4724-4739.
  • Meqdam MM, and Nasrallah GK. (2000). Enhanced detection of respiratory syncytial virus by shell vial in Children hospitalized with respiratory illnesses in northern Jordan. Journal of Medical Virology. 62: 518-523.
  • Nasrallah GK., Meqdam MM, and Al Shurman A. (2001). Parainfluenzae and influenzae viruses Infection among children with upper respiratory tract infection. Saudi Medical Journal. 21:1024-1029.
  • Meqdam MM, Nasrallah GK, Al Shurman A. (2001). Detection of adenovirus infection in children in Jordan. Annals of Tropical Pediatrics, 21: 59-65.
  • Nasrallah GK. M.Sc thesis. (1999). Respiratory Viral Infection Among Children Hospitalized with Respiratory Illnesses at Princess Rahma Hospital in Northern Jordan. Jordan University of Science and Technology, Irbid, Jordan

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